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Frequent mutation of the FOXA1 untranslated region in prostate cancer

Prostate cancer has a low somatic mutation rate but non-coding regions remain underexplored. We sequenced the untranslated regions (UTRs) of 72 established driver genes in 428 patients with metastatic prostate cancer and identified FOXA1 3′-UTR mutations in 12% of patients. The mutations were predom...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Commun Biol
Prif Awduron: Annala, Matti, Taavitsainen, Sinja, Vandekerkhove, Gillian, Bacon, Jack V. W., Beja, Kevin, Chi, Kim N., Nykter, Matti, Wyatt, Alexander W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6123809/
https://ncbi.nlm.nih.gov/pubmed/30272002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-018-0128-1
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