Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

BACKGROUND & AIMS: Defects in lysosome function and autophagy contribute to pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol consumption affects these processes, evaluating the functions transcription factor EB (TFEB), which regulates lysosomal biogenesis....

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Publié dans:Gastroenterology
Auteurs principaux: Chao, Xiaojuan, Wang, Shaogui, Zhao, Katrina, Li, Yuan, Williams, Jessica A, Li, Tiangang, Chavan, Hemantkumar, Krishnamurthy, Partha, He, Xi C, Li, Linheng, Ballabio, Andrea, Ni, Hong-Min, Ding, Wen-Xing
Format: Artigo
Langue:Inglês
Publié: 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120772/
https://ncbi.nlm.nih.gov/pubmed/29782848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.05.027
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