Critical Role of TFEB-Mediated Lysosomal Biogenesis in Alcohol-Induced Pancreatitis in Mice and Humans

BACKGROUND & AIMS: Alcohol abuse is the major cause of experimental and human pancreatitis but the molecular mechanisms remain largely unknown. We investigated the role of transcription factor EB (TFEB), a master regulator of lysosomal biogenesis, in the pathogenesis of alcoholic pancreatitis. M...

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Publicat a:Cell Mol Gastroenterol Hepatol
Autors principals: Wang, Shaogui, Ni, Hong-Min, Chao, Xiaojuan, Ma, Xiaowen, Kolodecik, Thomas, De Lisle, Robert, Ballabio, Andrew, Pacher, Pal, Ding, Wen-Xing
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2020
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7210479/
https://ncbi.nlm.nih.gov/pubmed/31987928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2020.01.008
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