Impaired TFEB-mediated lysosomal biogenesis promotes the development of pancreatitis in mice and is associated with human pancreatitis

Impaired macroautophagy/autophagy has been implicated in experimental and human pancreatitis. However, the transcriptional control governing the autophagy-lysosomal process in pancreatitis is largely unknown. We investigated the role and mechanisms of TFEB (transcription factor EB), a master regulat...

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Veröffentlicht in:Autophagy
Hauptverfasser: Wang, Shaogui, Ni, Hong-Min, Chao, Xiaojuan, Wang, Hua, Bridges, Brian, Kumer, Sean, Schmitt, Timothy, Mareninova, Olga, Gukovskaya, Anna, De Lisle, Robert C., Ballabio, Andrea, Pacher, Pal, Ding, Wen-Xing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6844531/
https://ncbi.nlm.nih.gov/pubmed/30894069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1596486
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