Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

BACKGROUND & AIMS: Defects in lysosome function and autophagy contribute to pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol consumption affects these processes, evaluating the functions transcription factor EB (TFEB), which regulates lysosomal biogenesis....

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Detalhes bibliográficos
Publicado no:Gastroenterology
Main Authors: Chao, Xiaojuan, Wang, Shaogui, Zhao, Katrina, Li, Yuan, Williams, Jessica A, Li, Tiangang, Chavan, Hemantkumar, Krishnamurthy, Partha, He, Xi C, Li, Linheng, Ballabio, Andrea, Ni, Hong-Min, Ding, Wen-Xing
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120772/
https://ncbi.nlm.nih.gov/pubmed/29782848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.05.027
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