Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

BACKGROUND & AIMS: Defects in lysosome function and autophagy contribute to pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol consumption affects these processes, evaluating the functions transcription factor EB (TFEB), which regulates lysosomal biogenesis....

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Vydáno v:Gastroenterology
Hlavní autoři: Chao, Xiaojuan, Wang, Shaogui, Zhao, Katrina, Li, Yuan, Williams, Jessica A, Li, Tiangang, Chavan, Hemantkumar, Krishnamurthy, Partha, He, Xi C, Li, Linheng, Ballabio, Andrea, Ni, Hong-Min, Ding, Wen-Xing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120772/
https://ncbi.nlm.nih.gov/pubmed/29782848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.05.027
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