Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

BACKGROUND & AIMS: Defects in lysosome function and autophagy contribute to pathogenesis of alcoholic liver disease. We investigated the mechanisms by which alcohol consumption affects these processes, evaluating the functions transcription factor EB (TFEB), which regulates lysosomal biogenesis....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Gastroenterology
Prif Awduron: Chao, Xiaojuan, Wang, Shaogui, Zhao, Katrina, Li, Yuan, Williams, Jessica A, Li, Tiangang, Chavan, Hemantkumar, Krishnamurthy, Partha, He, Xi C, Li, Linheng, Ballabio, Andrea, Ni, Hong-Min, Ding, Wen-Xing
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2018
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120772/
https://ncbi.nlm.nih.gov/pubmed/29782848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2018.05.027
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