Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy

The protein chaperones heat shock protein 70 (Hsp70) and Hsp90 are required for de novo folding of proteins and protect against misfolding-related cellular stresses by directing misfolded or slowly folding proteins to the ubiquitin/proteasome system (UPS) or autophagy/lysosomal degradation pathways....

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Hutt, Darren M., Mishra, Sanjay Kumar, Roth, Daniela Martino, Larsen, Mads Breum, Angles, Frédéric, Frizzell, Raymond A., Balch, William E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Protein Synthesis and Degradation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6120199/
https://ncbi.nlm.nih.gov/pubmed/29986884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.002607
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