Cysteine String Protein Promotes Proteasomal Degradation of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) by Increasing Its Interaction with the C Terminus of Hsp70-interacting Protein and Promoting CFTR Ubiquitylation

Cysteine string protein (Csp) is a J-domain-containing protein whose overexpression blocks the exit of cystic fibrosis transmembrane conductance regulator (CFTR) from the endoplasmic reticulum (ER). Another method of blocking ER exit, the overexpression of Sar1-GTP, however, yielded twice as much im...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Schmidt, Béla Z., Watts, Rebecca J., Aridor, Meir, Frizzell, Raymond A.
التنسيق: Artigo
اللغة:Inglês
منشور في: American Society for Biochemistry and Molecular Biology 2009
الموضوعات:
Protein Synthesis, Post-Translational Modification, and Degradation
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640980/
https://ncbi.nlm.nih.gov/pubmed/19098309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M806485200
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