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Placing a Disrupted Degradation Motif at the C Terminus of Proteasome Substrates Attenuates Degradation without Impairing Ubiquitylation

Protein elimination by the ubiquitin-proteasome system requires the presence of a cis-acting degradation signal. Efforts to discern degradation signals of misfolded proteasome substrates thus far revealed a general mechanism whereby the exposure of cryptic hydrophobic motifs provides a degradation d...

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Detalhes bibliográficos
Main Authors: Alfassy, Omri S., Cohen, Itamar, Reiss, Yuval, Tirosh, Boaz, Ravid, Tommer
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3642311/
https://ncbi.nlm.nih.gov/pubmed/23519465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453027
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