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Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4

Monomethylation of histone H3 lysine 4 (H3K4me1) is enriched at enhancers that are primed for activation and the levels of this histone mark are frequently altered in various human cancers. Yet, how alterations in H3K4me1 are established and the consequences of these epigenetic changes in tumorigene...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Rahnamoun, Homa, Hong, Juyeong, Sun, Zhengxi, Lee, Jihoon, Lu, Hanbin, Lauberth, Shannon M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6109924/
https://ncbi.nlm.nih.gov/pubmed/29954944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003387
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