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Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4
Monomethylation of histone H3 lysine 4 (H3K4me1) is enriched at enhancers that are primed for activation and the levels of this histone mark are frequently altered in various human cancers. Yet, how alterations in H3K4me1 are established and the consequences of these epigenetic changes in tumorigene...
Shranjeno v:
| izdano v: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2018
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6109924/ https://ncbi.nlm.nih.gov/pubmed/29954944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003387 |
| Oznake: |
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