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Mutant p53 shapes the enhancer landscape of cancer cells in response to chronic immune signaling

Inflammation influences cancer development, progression, and the efficacy of cancer treatments, yet the mechanisms by which immune signaling drives alterations in the cancer cell transcriptome remain unclear. Using ChIP-seq, RNA-seq, and GRO-seq, here we demonstrate a global overlap in the binding o...

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Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Rahnamoun, Homa, Lu, Hanbin, Duttke, Sascha H., Benner, Christopher, Glass, Christopher K., Lauberth, Shannon M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622043/
https://ncbi.nlm.nih.gov/pubmed/28963538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01117-y
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