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RNAs Interact with BRD4 to Promote Enhanced Chromatin Engagement and Transcription Activation
Bromodomain and extra-terminal motif (BET) protein BRD4 binds to acetylated histones at enhancers and promoters through its bromodomains (BDs) to regulate transcriptional elongation. Here, we reveal in human colorectal cancer cells that BRD4 is recruited to enhancers that are co-occupied by mutant p...
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| Publicado no: | Nat Struct Mol Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6859054/ https://ncbi.nlm.nih.gov/pubmed/30076409 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-018-0102-0 |
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