H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development

Histone 3 lysine 4 (H3K4) methyltransferases MLL3 and MLL4 (MLL3/4) are required for enhancer activation during cell differentiation, though the mechanism is incompletely understood. We have attempted to address this issue by generating two mouse lines: one expressing H3.3K4M, a lysine-4-to-methioni...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Jang, Younghoon, Broun, Aaron, Wang, Chaochen, Park, Young-Kwon, Zhuang, Lenan, Lee, Ji-Eun, Froimchuk, Eugene, Liu, Chengyu, Ge, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6344897/
https://ncbi.nlm.nih.gov/pubmed/30335158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky982
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