H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these enzymes function on enhancers to regulate cel...

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Detalhes bibliográficos
Main Authors: Lee, Ji-Eun, Wang, Chaochen, Xu, Shiliyang, Cho, Young-Wook, Wang, Lifeng, Feng, Xuesong, Baldridge, Anne, Sartorelli, Vittorio, Zhuang, Lenan, Peng, Weiqun, Ge, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2013
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869375/
https://ncbi.nlm.nih.gov/pubmed/24368734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01503
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