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H3K4 methyltransferase activity is required for MLL4 protein stability
Transcriptional enhancers play a key role in cell type-specific gene expression and cell fate transition. Enhancers are marked by histone H3K4 mono- and di-methylation (H3K4me1/2). The tumor suppressor MLL4 (KMT2D) is a major enhancer H3K4 mono- and di-methyltransferase with a partial functional red...
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| Publicado no: | J Mol Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5474351/ https://ncbi.nlm.nih.gov/pubmed/28013028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.12.016 |
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