H3K4 methyltransferase activity is required for MLL4 protein stability

Transcriptional enhancers play a key role in cell type-specific gene expression and cell fate transition. Enhancers are marked by histone H3K4 mono- and di-methylation (H3K4me1/2). The tumor suppressor MLL4 (KMT2D) is a major enhancer H3K4 mono- and di-methyltransferase with a partial functional red...

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Udgivet i:J Mol Biol
Main Authors: Jang, Younghoon, Wang, Chaochen, Zhuang, Lenan, Liu, Chengyu, Ge, Kai
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474351/
https://ncbi.nlm.nih.gov/pubmed/28013028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2016.12.016
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