H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation

Enhancers play a central role in cell-type-specific gene expression and are marked by H3K4me1/2. Active enhancers are further marked by H3K27ac. However, the methyltransferases responsible for H3K4me1/2 on enhancers remain elusive. Furthermore, how these enzymes function on enhancers to regulate cel...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Lee, Ji-Eun, Wang, Chaochen, Xu, Shiliyang, Cho, Young-Wook, Wang, Lifeng, Feng, Xuesong, Baldridge, Anne, Sartorelli, Vittorio, Zhuang, Lenan, Peng, Weiqun, Ge, Kai
التنسيق: Artigo
اللغة:Inglês
منشور في: eLife Sciences Publications, Ltd 2013
الموضوعات:
Cell Biology
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869375/
https://ncbi.nlm.nih.gov/pubmed/24368734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.01503
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