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Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels

Synthetic gabapentinoids, exemplified by gapapentin and pregabalin, are in extensive clinical use for indications including epilepsy, neuropathic pain, anxiety, and alcohol withdrawal. Their mechanisms of action are incompletely understood, but are thought to involve inhibition of α(2)δ subunit–cont...

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Publicado en:Mol Pharmacol
Autores principales: Manville, Rían W., Abbott, Geoffrey W.
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6108572/
https://ncbi.nlm.nih.gov/pubmed/30021858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112953
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