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Ancient and modern anticonvulsants act synergistically in a KCNQ potassium channel binding pocket

Epilepsy has been treated for centuries with herbal remedies, including leaves of the African shrub Mallotus oppositifolius, yet the underlying molecular mechanisms have remained unclear. Voltage-gated potassium channel isoforms KCNQ2–5, predominantly KCNQ2/3 heteromers, underlie the neuronal M-curr...

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書目詳細資料
發表在:Nat Commun
Main Authors: Manville, Rían W., Abbott, Geoffrey W.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2018
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6155021/
https://ncbi.nlm.nih.gov/pubmed/30242262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06339-2
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