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M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate

Ketogenic diets are effective therapies for refractory epilepsy, yet the underlying mechanisms are incompletely understood. The anticonvulsant efficacy of ketogenic diets correlates positively to the serum concentration of β-hydroxybutyrate (BHB), the primary ketone body generated by ketosis. Voltag...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Manville, Rían W., Papanikolaou, Maria, Abbott, Geoffrey W.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994816/
https://ncbi.nlm.nih.gov/pubmed/31757819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.263350
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