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M-Channel Activation Contributes to the Anticonvulsant Action of the Ketone Body β-Hydroxybutyrate

Ketogenic diets are effective therapies for refractory epilepsy, yet the underlying mechanisms are incompletely understood. The anticonvulsant efficacy of ketogenic diets correlates positively to the serum concentration of β-hydroxybutyrate (BHB), the primary ketone body generated by ketosis. Voltag...

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Pubblicato in:J Pharmacol Exp Ther
Autori principali: Manville, Rían W., Papanikolaou, Maria, Abbott, Geoffrey W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Pharmacology and Experimental Therapeutics 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994816/
https://ncbi.nlm.nih.gov/pubmed/31757819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.263350
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