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In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner
Voltage-gated potassium (Kv) channel dysfunction causes a variety of inherited disorders, but developing small molecules that activate Kv channels has proven challenging. We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and K...
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| Publicado no: | Commun Biol |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6825221/ https://ncbi.nlm.nih.gov/pubmed/31701029 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0648-3 |
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