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In silico re-engineering of a neurotransmitter to activate KCNQ potassium channels in an isoform-specific manner

Voltage-gated potassium (Kv) channel dysfunction causes a variety of inherited disorders, but developing small molecules that activate Kv channels has proven challenging. We recently discovered that the inhibitory neurotransmitter γ-aminobutyric acid (GABA) directly activates Kv channels KCNQ3 and K...

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Publicado en:Commun Biol
Autores principales: Manville, Rían W., Abbott, Geoffrey W.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6825221/
https://ncbi.nlm.nih.gov/pubmed/31701029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0648-3
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