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Gabapentin Is a Potent Activator of KCNQ3 and KCNQ5 Potassium Channels
Synthetic gabapentinoids, exemplified by gapapentin and pregabalin, are in extensive clinical use for indications including epilepsy, neuropathic pain, anxiety, and alcohol withdrawal. Their mechanisms of action are incompletely understood, but are thought to involve inhibition of α(2)δ subunit–cont...
Guardat en:
| Publicat a: | Mol Pharmacol |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The American Society for Pharmacology and Experimental Therapeutics
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6108572/ https://ncbi.nlm.nih.gov/pubmed/30021858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.118.112953 |
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