Exploration of Benzothiazole-Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70)

Cancer cells rely on the chaperone, heat shock protein 70 (Hsp70), for survival and proliferation. Recently, benzothiazole-rhodacyanines have been shown to bind an allosteric site on Hsp70, interrupting its binding to nucleotide-exchange factors (NEFs) and promoting cell death in breast cancer cell...

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Publicado en:J Med Chem
Main Authors: Shao, Hao, Li, Xiaokai, Moses, Michael A., Gilbert, Luke A., Kalyanaraman, Chakrapani, Young, Zapporah T., Chernova, Margarita, Journey, Sara N., Weissman, Jonathan S., Hann, Byron, Jacobson, Matthew P., Neckers, Len, Gestwicki, Jason E.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6104643/
https://ncbi.nlm.nih.gov/pubmed/29953808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00583
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