Combined effect of non-bacteriolytic antibiotic and inhibition of matrix metalloproteinases prevents brain injury and preserves learning, memory and hearing function in experimental paediatric pneumococcal meningitis

BACKGROUND: Pneumococcal meningitis is associated with high mortality and morbidity rates. Up to 50% of survivors show neurologic sequelae including hearing loss, cognitive impairments and learning disabilities, being particularly detrimental in affected infants and children where adjuvant therapy w...

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Publicat a:J Neuroinflammation
Autors principals: Muri, Lukas, Grandgirard, Denis, Buri, Michelle, Perny, Michael, Leib, Stephen L.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2018
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103863/
https://ncbi.nlm.nih.gov/pubmed/30131074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-018-1272-8
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