Combining Ceftriaxone with Doxycycline and Daptomycin Reduces Mortality, Neuroinflammation, Brain Damage, and Hearing Loss in Infant Rat Pneumococcal Meningitis

Despite appropriate antibiotic therapy, pneumococcal meningitis (PM) is associated with a case fatality rate of up to 30% in high-income countries. Survivors often suffer from severe lifelong disabilities. An excessive inflammatory reaction drives the pathophysiology, leading to brain damage and neu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Muri, Lukas, Perny, Michael, Zemp, Jonas, Grandgirard, Denis, Leib, Stephen L.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2019
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6591596/
https://ncbi.nlm.nih.gov/pubmed/31061158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00220-19
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