Adjunctive Daptomycin Attenuates Brain Damage and Hearing Loss More Efficiently than Rifampin in Infant Rat Pneumococcal Meningitis

Exacerbation of cerebrospinal fluid (CSF) inflammation in response to bacteriolysis by beta-lactam antibiotics contributes to brain damage and neurological sequelae in bacterial meningitis. Daptomycin, a nonlytic antibiotic acting on Gram-positive bacteria, lessens inflammation and brain injury comp...

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Hlavní autoři: Grandgirard, Denis, Burri, Melchior, Agyeman, Philipp, Leib, Stephen L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421563/
https://ncbi.nlm.nih.gov/pubmed/22644021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00674-12
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