Metformin mediates neuroprotection and attenuates hearing loss in experimental pneumococcal meningitis

Abstract Background Pneumococcal meningitis is associated with high risk of neurological sequelae such as cognitive impairment and hearing loss. These sequelae are due to parenchymal brain and inner ear damage primarily induced by the excessive inflammatory reaction in response to bacterial brain in...

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Main Authors: Lukas Muri, Ngoc Dung Le, Jonas Zemp, Denis Grandgirard, Stephen L. Leib
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-07-01
Colecção:Journal of Neuroinflammation
Assuntos:
Pneumococcal meningitis
Brain injury
Neuroinflammation
Neurologic sequelae
Metformin
Inner ear damage
Acesso em linha:http://link.springer.com/article/10.1186/s12974-019-1549-6
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