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Matrix Metalloproteinase Inhibition Lowers Mortality and Brain Injury in Experimental Pneumococcal Meningitis

Pneumococcal meningitis (PM) results in high mortality rates and long-lasting neurological deficits. Hippocampal apoptosis and cortical necrosis are histopathological correlates of neurofunctional sequelae in rodent models and are frequently observed in autopsy studies of patients who die of PM. In...

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Bibliografske podrobnosti
Main Authors: Liechti, Fabian D., Grandgirard, Denis, Leppert, David, Leib, Stephen L.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3993388/
https://ncbi.nlm.nih.gov/pubmed/24491581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00073-14
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