Doxycycline Reduces Mortality and Injury to the Brain and Cochlea in Experimental Pneumococcal Meningitis

Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that p...

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Detalhes bibliográficos
Main Authors: Meli, Damian N., Coimbra, Roney S., Erhart, Dominik G., Loquet, Gerard, Bellac, Caroline L., Täuber, Martin G., Neumann, Ulf, Leib, Stephen L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Host Response and Inflammation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489684/
https://ncbi.nlm.nih.gov/pubmed/16790761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01949-05
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