A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

PURPOSE: Conventional therapy for malignant glioma fails to specifically target tumor cells. In contrast, substantial evidence indicates that if appropriately redirected, T cells can precisely eradicate tumors. Here we report the rational development of a fully human bispecific antibody (hEGFRvIII-C...

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發表在:Clin Cancer Res
Main Authors: Gedeon, Patrick C., Schaller, Teilo H., Chitneni, Satish K., Choi, Bryan D., Kuan, Chien-Tsun, Suryadevara, Carter M., Snyder, David J., Schmittling, Robert J., Szafranski, Scott E., Cui, Xiuyu, Healy, Patrick N., Herndon, James E., McLendon, Roger E., Keir, Stephen T., Archer, Gary E., Reap, Elizabeth A., Sanchez-Perez, Luis, Bigner, Darell D., Sampson, John H.
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103776/
https://ncbi.nlm.nih.gov/pubmed/29703821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0126
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