A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

PURPOSE: Conventional therapy for malignant glioma fails to specifically target tumor cells. In contrast, substantial evidence indicates that if appropriately redirected, T cells can precisely eradicate tumors. Here we report the rational development of a fully human bispecific antibody (hEGFRvIII-C...

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I publikationen:Clin Cancer Res
Huvudupphovsmän: Gedeon, Patrick C., Schaller, Teilo H., Chitneni, Satish K., Choi, Bryan D., Kuan, Chien-Tsun, Suryadevara, Carter M., Snyder, David J., Schmittling, Robert J., Szafranski, Scott E., Cui, Xiuyu, Healy, Patrick N., Herndon, James E., McLendon, Roger E., Keir, Stephen T., Archer, Gary E., Reap, Elizabeth A., Sanchez-Perez, Luis, Bigner, Darell D., Sampson, John H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103776/
https://ncbi.nlm.nih.gov/pubmed/29703821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0126
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