A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma

PURPOSE: Conventional therapy for malignant glioma fails to specifically target tumor cells. In contrast, substantial evidence indicates that if appropriately redirected, T cells can precisely eradicate tumors. Here we report the rational development of a fully human bispecific antibody (hEGFRvIII-C...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Gedeon, Patrick C., Schaller, Teilo H., Chitneni, Satish K., Choi, Bryan D., Kuan, Chien-Tsun, Suryadevara, Carter M., Snyder, David J., Schmittling, Robert J., Szafranski, Scott E., Cui, Xiuyu, Healy, Patrick N., Herndon, James E., McLendon, Roger E., Keir, Stephen T., Archer, Gary E., Reap, Elizabeth A., Sanchez-Perez, Luis, Bigner, Darell D., Sampson, John H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6103776/
https://ncbi.nlm.nih.gov/pubmed/29703821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-0126
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