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Cancer Drug Development of Carbonic Anhydrase Inhibitors beyond the Active Site
Carbonic anhydrases (CAs) catalyze the reversible hydration of carbon dioxide to produce bicarbonate and a proton. Multiple CA isoforms are implicated in a range of diseases, including cancer. In solid tumors, continuously dividing cells create hypoxic conditions that eventually lead to an acidic mi...
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| Pubblicato in: | Molecules |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
MDPI
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6099549/ https://ncbi.nlm.nih.gov/pubmed/29710858 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23051045 |
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