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Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors

Carbonic anhydrases (CAs) are thought to be important for regulating pH in the tumor microenvironment. A few of the CA isoforms are upregulated in cancer cells, with only limited expression in normal cells. For these reasons, there is interest in developing inhibitors that target these tumor-associa...

詳細記述

保存先:
書誌詳細
出版年:Int J Med Chem
主要な著者: Mboge, Mam Y., Kota, Anusha, McKenna, Robert, Frost, Susan C.
フォーマット: Artigo
言語:Inglês
出版事項: Hindawi 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6077552/
https://ncbi.nlm.nih.gov/pubmed/30112206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/2906519
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