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Structure activity study of carbonic anhydrase IX: Selective inhibition with ureido-substituted benzenesulfonamides

Ureido-substituted benzenesulfonamides (USBs) show great promise as selective and potent inhibitors for human carbonic anhydrase hCA IX and XII, with one such compound (SLC-0111/U-F) currently in clinical trials (clinical trials.gov, NCT02215850). In this study, the crystal structures of both hCA II...

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Detalhes bibliográficos
Publicado no:Eur J Med Chem
Main Authors: Mboge, Mam Y., Mahon, Brian P., Lamas, Nicole, Socorro, Lillien, Carta, Fabrizio, Supuran, Claudiu T., Frost, Susan C., McKenna, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5946058/
https://ncbi.nlm.nih.gov/pubmed/28363153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2017.03.026
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