An ureido-substituted benzenesulfonamide carbonic anhydrase inhibitor exerts a potent antitumor effect in vitro and in vivo

Abstract Carbonic anhydrase IX (CA IX) is a tumor-specific metallo-enzyme upregulated during hypoxic conditions and implicated in several pathophysiological processes where tissue pH regulation is required such as cancer, cell invasion, metastatic and stem-like features, drug resistance and recurren...

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Detalhes bibliográficos

Principais autores:	Giorgia Gazzaroli, Camilla Tavani, Serena Filiberti, Maria Luisa Massardi, Marta Turati, Giulia Garattini, Thomas S. Peat, Giuseppe Pieraccini, Andrea Angeli, Claudiu T. Supuran, Fabrizio Carta, Arianna Giacomini, Roberto Ronca
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-08-01
coleção:	Experimental Hematology & Oncology
Assuntos:	Carbonic anhydrase inhibitor Cancer therapy Metastasis Benzenesulfonamide
Acesso em linha:	https://doi.org/10.1186/s40164-025-00690-z
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