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Advances in Anti-Cancer Drug Development Targeting Carbonic Anhydrase IX and XII

The microenvironment within a solid tumor is heterogeneous with regions being both acidic and hypoxic. As a result of this, cancer cells upregulate genes that allow survival in such environments. Some of these genes are pH regulatory factors, including carbonic anhydrase IX (CA IX) and in some cases...

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Bibliografske podrobnosti
izdano v:Top Anticancer Res
Main Authors: Mboge, Mam Y., McKenna, Robert, Frost, Susan C.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6162069/
https://ncbi.nlm.nih.gov/pubmed/30272043
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