The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

Human carbonic anhydrase IX (hCA IX) expression in many cancers is associated with hypoxic tumors and poor patient outcome. Inhibitors of hCA IX have been used as anticancer agents with some entering Phase I clinical trials. hCA IX is transmembrane protein whose catalytic domain faces the extracellu...

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Publicat a:Biochemistry
Autors principals: Mahon, Brian P., Bhatt, Avni, Socorro, Lilien, Driscoll, Jenna M., Okoh, Cynthia, Lomelino, Carrie L., Mboge, Mam Y., Kurian, Justin J., Tu, Chingkuang, Agbandje-McKenna, Mavis, Frost, Susan C., McKenna, Robert
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322481/
https://ncbi.nlm.nih.gov/pubmed/27439028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00243
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