The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

Human carbonic anhydrase IX (hCA IX) expression in many cancers is associated with hypoxic tumors and poor patient outcome. Inhibitors of hCA IX have been used as anticancer agents with some entering Phase I clinical trials. hCA IX is transmembrane protein whose catalytic domain faces the extracellu...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Biochemistry
Hoofdauteurs: Mahon, Brian P., Bhatt, Avni, Socorro, Lilien, Driscoll, Jenna M., Okoh, Cynthia, Lomelino, Carrie L., Mboge, Mam Y., Kurian, Justin J., Tu, Chingkuang, Agbandje-McKenna, Mavis, Frost, Susan C., McKenna, Robert
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
Onderwerpen:
Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322481/
https://ncbi.nlm.nih.gov/pubmed/27439028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00243
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items