The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis

Human carbonic anhydrase IX (hCA IX) expression in many cancers is associated with hypoxic tumors and poor patient outcome. Inhibitors of hCA IX have been used as anticancer agents with some entering Phase I clinical trials. hCA IX is transmembrane protein whose catalytic domain faces the extracellu...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Mahon, Brian P., Bhatt, Avni, Socorro, Lilien, Driscoll, Jenna M., Okoh, Cynthia, Lomelino, Carrie L., Mboge, Mam Y., Kurian, Justin J., Tu, Chingkuang, Agbandje-McKenna, Mavis, Frost, Susan C., McKenna, Robert
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322481/
https://ncbi.nlm.nih.gov/pubmed/27439028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00243
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