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The Structure of Carbonic Anhydrase IX Is Adapted for Low-pH Catalysis
Human carbonic anhydrase IX (hCA IX) expression in many cancers is associated with hypoxic tumors and poor patient outcome. Inhibitors of hCA IX have been used as anticancer agents with some entering Phase I clinical trials. hCA IX is transmembrane protein whose catalytic domain faces the extracellu...
Shranjeno v:
| izdano v: | Biochemistry |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5322481/ https://ncbi.nlm.nih.gov/pubmed/27439028 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00243 |
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