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Rigid Peptide Macrocycles via On-Resin Glaser Stapling
Peptide macrocycles are widely utilized in the development of high affinity ligands including stapled α-helices. The linear rigidity of a 1,3-diynyl linkage provides an optimal distance (7 Å) between β- carbons of the i, i+4 amino acid side chains, suggesting its utility in stabilizing α-helical str...
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| Udgivet i: | Chembiochem |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6097620/ https://ncbi.nlm.nih.gov/pubmed/29516601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201800121 |
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