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On-resin peptide macrocyclization using thiol-ene click chemistry
A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3969419/ https://ncbi.nlm.nih.gov/pubmed/20379591 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c001375g |
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