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Synthesis of cyclic, multivalent Arg-Gly-Asp using sequential thiol-ene/thiol-yne photoreactions

A unique method has been developed for the formation of multivalent cyclic peptides. This procedure exploits on-resin peptide cyclization using a photoinitiated thiol-ene click reaction and subsequent clustering using thiol-yne photochemistry. Both reactions utilize the sulfhydryl group on natural c...

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Detalhes bibliográficos
Main Authors: Aimetti, Alex A., Feaver, Kristen R., Anseth, Kristi S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3961633/
https://ncbi.nlm.nih.gov/pubmed/20552127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0cc01292k
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