KDM5 histone demethylases repress immune response via suppression of STING

Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate and adaptive immune responses and are a new class...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS Biol
Päätekijät: Wu, Lizhen, Cao, Jian, Cai, Wesley L., Lang, Sabine M., Horton, John R., Jansen, Daniel J., Liu, Zongzhi Z., Chen, Jocelyn F., Zhang, Meiling, Mott, Bryan T., Pohida, Katherine, Rai, Ganesha, Kales, Stephen C., Henderson, Mark J., Hu, Xin, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Zhu, Shu, Iwasaki, Akiko, Hall, Matthew D., Cheng, Xiaodong, Shadel, Gerald S., Yan, Qin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2018
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095604/
https://ncbi.nlm.nih.gov/pubmed/30080846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006134
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