KDM5 histone demethylases repress immune response via suppression of STING

Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate and adaptive immune responses and are a new class...

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Publicado en:PLoS Biol
Main Authors: Wu, Lizhen, Cao, Jian, Cai, Wesley L., Lang, Sabine M., Horton, John R., Jansen, Daniel J., Liu, Zongzhi Z., Chen, Jocelyn F., Zhang, Meiling, Mott, Bryan T., Pohida, Katherine, Rai, Ganesha, Kales, Stephen C., Henderson, Mark J., Hu, Xin, Jadhav, Ajit, Maloney, David J., Simeonov, Anton, Zhu, Shu, Iwasaki, Akiko, Hall, Matthew D., Cheng, Xiaodong, Shadel, Gerald S., Yan, Qin
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2018
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095604/
https://ncbi.nlm.nih.gov/pubmed/30080846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.2006134
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