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Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins

It is well accepted that the introduction of negative supercoils locally unwinds the DNA double helix, influencing thus the activity of proteins. Despite the use of recent methods of molecular dynamics simulations to model the DNA supercoiling-induced DNA deformation, the precise extent and location...

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Foilsithe in:PLoS One
Main Authors: Saintomé, Carole, Delagoutte, Emmanuelle
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095550/
https://ncbi.nlm.nih.gov/pubmed/30114256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202138
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