Cascade-mediated binding and bending of negatively supercoiled DNA

Prokaryotes possess various defense mechanisms against invading DNA. Adaptive defense by CRISPR/Cas relies on incorporation of invader DNA sequences in the host genome. In Escherichia coli, processed transcripts of these incorporated sequences (crRNAs) guide Cascade-mediated invader DNA recognition....

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Bibliographic Details
Main Authors: Westra, Edze R., Nilges, Benedikt, van Erp, Paul B. G., van der Oost, John, Dame, Remus T., Brouns, Stan J. J.
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3579878/
https://ncbi.nlm.nih.gov/pubmed/22954644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.21410
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