CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3

The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules, these sequences act as a memory to reject returning invaders. Both the Cascade ribonucleoprotein complex and the Cas3 nuclease/helicas...

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書誌詳細
主要な著者: Westra, Edze R., van Erp, Paul B. G., Künne, Tim, Wong, Shi Pey, Staals, Raymond H. J., Seegers, Christel L. C., Bollen, Sander, Jore, Matthijs M., Semenova, Ekaterina, Severinov, Konstantin, de Vos, Willem M., Dame, Remus T., de Vries, Renko, Brouns, Stan J. J., van der Oost, John
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372689/
https://ncbi.nlm.nih.gov/pubmed/22521689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.018
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