CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3

The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules, these sequences act as a memory to reject returning invaders. Both the Cascade ribonucleoprotein complex and the Cas3 nuclease/helicas...

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Detaylı Bibliyografya
Asıl Yazarlar: Westra, Edze R., van Erp, Paul B. G., Künne, Tim, Wong, Shi Pey, Staals, Raymond H. J., Seegers, Christel L. C., Bollen, Sander, Jore, Matthijs M., Semenova, Ekaterina, Severinov, Konstantin, de Vos, Willem M., Dame, Remus T., de Vries, Renko, Brouns, Stan J. J., van der Oost, John
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372689/
https://ncbi.nlm.nih.gov/pubmed/22521689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.018
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