Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts a...

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Detalhes bibliográficos
Main Authors: Westra, Edze R., Semenova, Ekaterina, Datsenko, Kirill A., Jackson, Ryan N., Wiedenheft, Blake, Severinov, Konstantin, Brouns, Stan J. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764190/
https://ncbi.nlm.nih.gov/pubmed/24039596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003742
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