Type I-E CRISPR-Cas Systems Discriminate Target from Non-Target DNA through Base Pairing-Independent PAM Recognition

Discriminating self and non-self is a universal requirement of immune systems. Adaptive immune systems in prokaryotes are centered around repetitive loci called CRISPRs (clustered regularly interspaced short palindromic repeat), into which invader DNA fragments are incorporated. CRISPR transcripts a...

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Autors principals: Westra, Edze R., Semenova, Ekaterina, Datsenko, Kirill A., Jackson, Ryan N., Wiedenheft, Blake, Severinov, Konstantin, Brouns, Stan J. J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3764190/
https://ncbi.nlm.nih.gov/pubmed/24039596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003742
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