CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3

The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules, these sequences act as a memory to reject returning invaders. Both the Cascade ribonucleoprotein complex and the Cas3 nuclease/helicas...

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Autori principali: Westra, Edze R., van Erp, Paul B. G., Künne, Tim, Wong, Shi Pey, Staals, Raymond H. J., Seegers, Christel L. C., Bollen, Sander, Jore, Matthijs M., Semenova, Ekaterina, Severinov, Konstantin, de Vos, Willem M., Dame, Remus T., de Vries, Renko, Brouns, Stan J. J., van der Oost, John
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372689/
https://ncbi.nlm.nih.gov/pubmed/22521689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.018
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