CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3

The prokaryotic CRISPR/Cas immune system is based on genomic loci that contain incorporated sequence tags from viruses and plasmids. Using small guide RNA molecules, these sequences act as a memory to reject returning invaders. Both the Cascade ribonucleoprotein complex and the Cas3 nuclease/helicas...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Westra, Edze R., van Erp, Paul B. G., Künne, Tim, Wong, Shi Pey, Staals, Raymond H. J., Seegers, Christel L. C., Bollen, Sander, Jore, Matthijs M., Semenova, Ekaterina, Severinov, Konstantin, de Vos, Willem M., Dame, Remus T., de Vries, Renko, Brouns, Stan J. J., van der Oost, John
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3372689/
https://ncbi.nlm.nih.gov/pubmed/22521689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2012.03.018
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg