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Probing hyper-negatively supercoiled mini-circles with nucleases and DNA binding proteins

It is well accepted that the introduction of negative supercoils locally unwinds the DNA double helix, influencing thus the activity of proteins. Despite the use of recent methods of molecular dynamics simulations to model the DNA supercoiling-induced DNA deformation, the precise extent and location...

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Vydáno v:PLoS One
Hlavní autoři: Saintomé, Carole, Delagoutte, Emmanuelle
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6095550/
https://ncbi.nlm.nih.gov/pubmed/30114256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0202138
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