Measuring NDC80 binding reveals the molecular basis of tension-dependent kinetochore-microtubule attachments

Proper kinetochore-microtubule attachments, mediated by the NDC80 complex, are required for error-free chromosome segregation. Erroneous attachments are corrected by the tension dependence of kinetochore-microtubule interactions. Here, we present a method, based on fluorescence lifetime imaging micr...

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Vydáno v:eLife
Hlavní autoři: Yoo, Tae Yeon, Choi, Jeong-Mo, Conway, William, Yu, Che-Hang, Pappu, Rohit V, Needleman, Daniel J
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6089600/
https://ncbi.nlm.nih.gov/pubmed/30044223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.36392
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